BCMA-Luc K562
CBP74667
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| I. Background | |
| BCMA（B细胞成熟抗原）是TNF受体超家族成员，由TNFRSF17基因编码，主要表达于浆细胞和成熟B细胞表面。它在多发性骨髓瘤细胞上高表达，是浆细胞存活的关键分子，也是CAR-T、双特异性抗体和ADC等抗骨髓瘤疗法最重要的靶点之一。 | |
| II. Description | |
| BCMA-Luc K562 细胞，在K562细胞的基础上，稳定表达 BCMA。 | |
| III. Introduction | |
| Expressed gene: | BCMA-Luc |
| Host Cell: | K562 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | RPMI-1640 +10%FBS +5μg/ml Blasticidin +1 μg/ml Puromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Representative Data | |
 Figure 1. Recombinant BCMA-Luc K562 constitutively expressing BCMA.  Figure 2. Detect Luciferase assay by Ultra Luciferase Detection Kit CBPH0001（we strongly recommend purchasing from Cobioer).The luminescence signal can be robustly and stably detected in BCMA-Luc K562 cells, and BCMA-Luc K562 cells maintain stable luminescence intensity for at least 32 passages. |
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